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| ID | Type | Description | Link |
|---|---|---|---|
| 2008ZX10001-016 | Other Grant/Funding Number | Ministry of Health, the People's Republic of China |
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| Name | Class |
|---|---|
| Yunnan Center for Disease Control and Prevention | OTHER |
| Xinjiang Center for Disease Control and Prevention | OTHER |
| Sichuan Center for Disease Control and Prevention | OTHER_GOV |
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The purpose of this study is to reduce the HIV/HCV incidence among the clients attending community-based methadone maintenance treatment (MMT) , and to prevent the secondary sexual transmission from HIV+ clients to their spouse and sex partners, through intensified comprehensive intervention.
Even though National sentinel surveillance data show that the increase rate of HIV new infections among IDUs in China has become stabilized and slowed down, the new HIV infection is still on the rise, especially in the Yunnan, Guizhou, Guangxi, Xinjiang and Sichuan. This study attempts to further reduce the new infection among MMT clients, and particularly to prevent the transmission from HIV infected clients to their sexual partners with comprehensive intervention.
The purposes of this study are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | Intensive HIV psychological counseling ,Increased methadone dosage under individualized treatment principle, enhance randomized urine test, strengthen family and social support , partner notification and routine HIV testing, condom promotion, STD referral services. |
|
| Usual | No Intervention | Routine HIV prevention, including health education, counseling and testing, condom promotion. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intervention | Behavioral | Intensive HIV psychological counseling ,Increased methadone dosage under individualized treatment principle, enhance randomized urine test, strengthen family and social support , partner notification and routine HIV testing, condom promotion, STD referral services. |
| Measure | Description | Time Frame |
|---|---|---|
| HIV incidence rate | August 1,2009 to 31,Mar,2011 |
| Measure | Description | Time Frame |
|---|---|---|
| HCV, Syphilis, HSV-2 incidence | 1,Aug.,2009 to 31,Mar,2011 | |
| MMT Retention Rate and Lapse/Relapse Rate | 1,Aug.,2009 to 31,Mar,2011 | |
| Frequency of condom uses |
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(1) For MMT clients:
Inclusion Criteria:
Exclusion Criteria:
For the spouse or sex partners of MMT HIV+ clients'
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zunyou Wu, MD, PHD | Contact | 86-10-58900900 | wuzy@chinacdc.cn | |
| Wenyuan Yin, MD, MS | Contact | 86-10-58900951 | yinwy928@yahoo.com.cn |
| Name | Affiliation | Role |
|---|---|---|
| Zunyou Wu, MD, PHD | National Center for AIDS/STD Control and Prevention, China CDC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Disease Control and Prevention,Guangxi Zhuang Autonomous Region | Recruiting | Nanning | Guangxi | 530028 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16771892 | Background | Costenbader EC, Astone NM, Latkin CA. The dynamics of injection drug users' personal networks and HIV risk behaviors. Addiction. 2006 Jul;101(7):1003-13. doi: 10.1111/j.1360-0443.2006.01431.x. | |
| 15099661 | Background | Booth RE, Corsi KF, Mikulich-Gilbertson SK. Factors associated with methadone maintenance treatment retention among street-recruited injection drug users. Drug Alcohol Depend. 2004 May 10;74(2):177-85. doi: 10.1016/j.drugalcdep.2003.12.009. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D006526 | Hepatitis C |
| D013587 | Syphilis |
| D015658 | HIV Infections |
| D000076064 | Drug Misuse |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D006525 | Hepatitis, Viral, Human |
Not provided
Not provided
| ID | Term |
|---|---|
| D008722 | Methods |
| ID | Term |
|---|---|
| D008919 | Investigative Techniques |
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Not provided
| Guangxi Center for Disease Control and Prevention |
| OTHER_GOV |
| Guizhou Center for Disease Control and Prevention | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
|
|
| 1,Aug.,2009 to 31, Mar,2011 |
| The awareness of HIV-related Information among the clients [ | 1,Aug.,2009 to 31,Mar,2011 |
| The proportion of discordant couple/partners receiving HIV testing | 1,Aug.,2009 to 31,Dec,2010 |
| Center for Disease Control and Prevention, Guizhou Province | Recruiting | Guiyang | Guizhou | 550004 | China |
|
| Center for Disease Control and Prevention, Sichuan Province | Recruiting | Chengdu | Sichuan | 610041 | China |
|
| Center for Disease Control and Prevention, Xingjiang Uyghur Autonomous Region | Recruiting | Ürümqi | Xingjiang Uyghur Autonomous Region | 830002 | China |
|
| Center for Disease Control and Prevention, Yunnan Province | Recruiting | Kunming | Yunnan | 650022 | China |
|
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| Background | International Harm Reduction Development Program of the Open Society Institute. Saving lives by reducing harm: HIV prevention and treatment for injecting drug users. New York City, USA; 2006. |
| Background | Ball A, Beg M, Doupe A, Weiler G. World Health Organization, Evidence for Action for HIV Prevention, Treatment and Care among Injecting Drug Users. The International Journal of Drug Policy. 2005;16. |
| 10618778 | Background | de la Fuente L, Bravo MJ, Lew C, Barrio G, Soriano V, Royuela L. [The prevalence of human immunodeficiency virus infection and the risk behaviors in the heroin addicts of Barcelona, Madrid and Seville: an example of the advantages of centering studies on addicts and not just on intravenous users]. Med Clin (Barc). 1999 Nov 20;113(17):646-51. Spanish. |
| 12045494 | Background | Welp EA, Lodder AC, Langendam MW, Coutinho RA, van Ameijden EJ. HIV prevalence and risk behaviour in young drug users in Amsterdam. AIDS. 2002 Jun 14;16(9):1279-84. doi: 10.1097/00002030-200206140-00011. |
| 15136659 | Background | Garfein RS, Monterroso ER, Tong TC, Vlahov D, Des Jarlais DC, Selwyn P, Kerndt PR, Word C, Fernando MD, Ouellet LJ, Holmberg SD. Comparison of HIV infection risk behaviors among injection drug users from East and West Coast US cities. J Urban Health. 2004 Jun;81(2):260-7. doi: 10.1093/jurban/jth112. |
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| 11470340 | Background | Gogineni A, Stein MD, Friedmann PD. Social relationships and intravenous drug use among methadone maintenance patients. Drug Alcohol Depend. 2001 Sep 1;64(1):47-53. doi: 10.1016/s0376-8716(00)00230-1. |
| 9722816 | Background | Hartel DM, Schoenbaum EE. Methadone treatment protects against HIV infection: two decades of experience in the Bronx, New York City. Public Health Rep. 1998 Jun;113 Suppl 1(Suppl 1):107-15. |
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| 17411414 | Background | Des Jarlais DC, Braine N, Yi H, Turner C. Residual injection risk behavior, HIV infection, and the evaluation of syringe exchange programs. AIDS Educ Prev. 2007 Apr;19(2):111-23. doi: 10.1521/aeap.2007.19.2.111. |
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| D014777 |
| Virus Diseases |
| D018178 | Flaviviridae Infections |
| D012327 | RNA Virus Infections |
| D006505 | Hepatitis |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D014211 | Treponemal Infections |
| D013145 | Spirochaetales Infections |
| D016905 | Gram-Negative Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D015231 | Sexually Transmitted Diseases, Bacterial |
| D012749 | Sexually Transmitted Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D015229 | Sexually Transmitted Diseases, Viral |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |