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| ID | Type | Description | Link |
|---|---|---|---|
| 2009-A00968-49 | Other Identifier | ANSM |
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Inclusion curve too slow.
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Despite the fact that a link between cholesterol and the myometrium has been clearly established, no study investigating aspects of cholesterol metabolism and uterine dystocia currently exists. This study is a pilot study whose aim is to test the hypothesis that an association between uterine dystocia and single-nucleotide polymorphisms (SNPs) in the genes coding for the LXRs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Control group: these patients have mechanical dystocia; cholesterol metabolism factors are a priori not involved. |
| |
| Group 2 | These patients have uterine dystocia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whole blood sampling | Biological | Whole blood sampling for SNP polymorphism analysis |
|
| Measure | Description | Time Frame |
|---|---|---|
| The multi-loci genotype of the target DNA sequence. | The polymorphisms of interest are the following SNPs: rs3758673, rs3758674, rs12221497, rs11039155, rs2279238, rs7120118, rs35463555, rs1052533, rs2248949, rs41432149, rs1405655, rs4802703. | Day 1 |
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Inclusion Criteria:
Exclusion Criteria:
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The study population represents women undergoing a difficult, stagnating labor due to either physical or uterine dystocia.
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| Name | Affiliation | Role |
|---|---|---|
| Kevin Mouzat, PhD | Centre Hospitalier Universitaire de Nīmes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Universitaire de Nîmes | Nîmes | 30029 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27510420 | Result | Mouzat K, Raoul C, Polge A, Kantar J, Camu W, Lumbroso S. Liver X receptors: from cholesterol regulation to neuroprotection-a new barrier against neurodegeneration in amyotrophic lateral sclerosis? Cell Mol Life Sci. 2016 Oct;73(20):3801-8. doi: 10.1007/s00018-016-2330-y. Epub 2016 Aug 10. |
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| ID | Term |
|---|---|
| D014593 | Uterine Inertia |
| D004420 | Dystocia |
| ID | Term |
|---|---|
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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A whole blood sample is taken and DNA extracted using Qiagen kits.