The primary objective of this study is to compare the duration of subject reported comfortable contact lens daily wear time in subjects with a history and current complaint of CLDE during a 29-day treatment period of azithromycin ophthalmic solution, 1%, compared to rewetting drops

Inclusion Criteria:

• Have a history of and current complaint of CLDE.
• Use properly fitted daily-wear soft contact lenses.
• Able to wear contact lenses for at least 8 hours a day.
• If female, are non-pregnant or non-lactating.

Exclusion Criteria:

• Have changed brand of contact lens or care solutions within one month prior to Visit 1.
• Use extended (overnight) wear contact lenses.
• Have a clinically significant ophthalmic abnormality.
• Have had cauterization of the punctum or have had punctal plugs (silicone or collagen) inserted or removed within the 90 days prior to the screening.
• Have any active ongoing ocular infection or ocular disease.
• Have a serious medical condition which could confound study assessments.