Target Volume Mode Controlled Ventilator in Obesity Hypoventilation Syndrome

Target Volume With a Pressure Controlled Ventilator in Obesity Hypoventilation Syndrome With Persistent Oxygen Desaturations With Continuous Positive Airway Pressure

The purpose of this study is to investigate the evolution of daytime partial pressure of carbon dioxide in the blood (PaCO2) after 6 weeks of noninvasive ventilation-pressure support ventilation (NIV-PSV) with target volume versus continuous positive airway pressure (CPAP) alone versus NIV-PSV.

Compare the efficacy between 3 ventilation modes (CPAP, PSV and PSV with Target Volume) on patients with obesity hypoventilation syndrome already treated with CPAP but with persistent desaturations.

Inclusion Criteria:

• Patients from 20 to 75 years old.
• Body mass index > 32 kg/m2
• Nocturnal oxygen desaturation 5 mn ≤ 88% under CPAP,
• PaCO2 > 5,9 kPa in diurnal, spontaneous ventilation

Exclusion Criteria:

• Patients with COPD and VEMS/FVC < 65%
• Patients with CHF and periodic breathing (Ejection Fraction <40%)
• Patients with a recent respiratory decompensation in the month preceding inclusion