A Study of Niaspan on Endothelium-Dependent and Endothelium-Independent Vascular Reactivity (0000-093)

A Randomized, Double-Blind, Placebo-Controlled, 2-Period Crossover Study to Evaluate the Effects of Multiple Oral Doses of 2000 mg of Niaspan on Endothelium-Dependent and Endothelium-Independent Vascular Reactivity in Subjects With Hypercholesterolemia

A study to evaluate the inter- and intra subject variabilities of flow-mediated dilation (FMD) of brachial artery and nitroglycerin (GTN) induced dilation of brachial artery.

Inclusion Criteria:

• Female subjects of reproductive potential test negative for pregnancy and agree to use appropriate methods of contraception throughout the study
• Subject is in good health (other than history of high cholesterol)
• Subject is a non-smoker

Exclusion Criteria:

• Subject has a history of stroke, seizures or major neurological disorder
• Subject has a history of cancer
• Subject is unable to refrain from or anticipates the use any prescription or non-prescription drugs
• Subjects consumes excessive amounts of alcohol or caffeine