Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| C17 Council | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Acute lymphoblastic leukemia is the most common form of childhood cancer with current treatment survival rates approaching 80%. Improved outcomes show an increased number of survivors at risk for long-term treatment related side effects including osteonecrosis. Osteonecrosis, or bone death, is caused by blood supply loss to the bone causing pain and poor quality of life. The hips, shoulders, knees and ankles may be affected. Pain is the usual presenting symptom and may become severe requiring surgical decompression or replacement of the affected joint. Long-term effects including arthritis and progressive joint difficulties will not be known for decades. This study aims to determine the risk factors for developing osteonecrosis that will lead to information for earlier detection and prevention. The study will be the basis for future intervention and prevention trials.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| osteonecrosis 1 year post leukemia therapy | Each participant will undergo MRI of hip, knee, ankle and shoulder to look for ON | One year after completion of therapy for leukemia |
| Measure | Description | Time Frame |
|---|---|---|
| Bone mass density and Osteonecrosis | Is reductions in bone mass density at diagnosis of leukemia associated with the development of ON. These patients are a subset of a lagre study where Bone mass is being measured by DEXA. We will be able to access this data to look for bone mass density | One year post therapy for leukemia |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Patients with Acute lymphoblastic leukemia who have participated in the STOPP - CIS study will be eligible for this ancillary study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jacqueline Halton | Contact | 613 737 7600 | 2978 | |
| Lynda Hoey | Contact | 613 737 7600 | 4109 |
| Name | Affiliation | Role |
|---|---|---|
| Jacqueline Halton | Childrens Hospital of Easten Ontario | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Alberta Children's Hospital | Not yet recruiting | Calgary | Alberta | Canada |
Not provided
| ID | Term |
|---|---|
| D010020 | Osteonecrosis |
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| ID | Term |
|---|---|
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D009336 | Necrosis |
| D010335 | Pathologic Processes |
Not provided
Not provided
Not provided
Not provided
Not provided
Platlet free plasma
| Is Bone loss/failure to accure bone mineral and ON |
Is bone loss/failure to accrue bone mineral at a normal rate during chemotherapy is/are associated with the development of ON.These patients are a subset of a lagre study where Bone mass is being measured by DEXA. We will be able to access this data to look for bone loss |
| One year post leukemia therapy |
| Glucocorticoid dose and ON | Is there a glucocorticoid threshold dose, above which patients are more likely to develop ON. These patients are a subset of a lagre study where glucocorticoid dose is recorded. We will be able to access this data. | One year post Leukemia therapy |
| Methotrexate dose and ON | Is there a methotrexate threshold dose, above which patients are more likely to develop ON. These patients are a subset of a lagre study where Methotrexate dose is recorded. We will be able to access this data. | One year post leukemia therpy |
| Obesity and ON | Is obesity either at diagnosis or during therapy associated with ON. These patients are a subset of a larger group in a larger study. They are recording height weight and BMI. We will be able to access this data. | One year post leukemia therapy |
| Weight bearing and non weight bearing activities and ON | Does weight bearing and non-weight bearing activities play a role in the development of ON. These patients are a subset of a larger study. They are recording these activities. We will be able to use this data. | One year post leukrmia therapy |
| Hyperlipidemia and On | Is hyperlipidemia associated with the development of ON. Statins (cholesterol lowering medications) have been suggested as a therapeutic intervention to prevent ON. Fasting blood will be tested for lipids at at least one year post chemtherapy. | One year post leukemia therapy |
| Thrombophilia and ON | Is thrombophilia associated with the development of ON. Blood will be tested at study entry following one year completion of chemotherapy.Blood will be drawn for protein C, protein S, antithrombin, activated protein C resistance, Factor V Leiden, prothrombin gene complex, MTHFR, lupus anticoagulant and antiphospholipid antibodies and Lipoprotein A. | One year post leukemia therapy |
| Stollery Children's Hospital | Not yet recruiting | Edmonton | Alberta | Canada |
|
| BC Children's Hospital | Not yet recruiting | Vancouver | British Columbia | Canada |
|
| Winnipeg Children's Hospital | Not yet recruiting | Winnipeg | Manitoba | Canada |
|
| IWK Health Centre | Not yet recruiting | Halifax | Nova Scotia | Canada |
|
| Children's Hospital of Western Ontario | Not yet recruiting | London | Ontario | Canada |
|
| Childrens Hospital of Eastern Ontario | Recruiting | Ottawa | Ontario | Canada |
|
| Hospital for Sick Children | Not yet recruiting | Toronto | Ontario | Canada |
|
| Hopital Sainte-Justine | Not yet recruiting | Montreal | Quebec | Canada |
|
| Montreal Children's Hospital | Not yet recruiting | Montreal | Quebec | Canada |
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D007945 | Leukemia, Lymphoid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |