Pilot Study Using a Wireless Motility Capsule

Measurement of Whole Gut Transit Time After a Dietary Fiber Treatment Using a Wireless Motility Capsule

Research suggests dietary fiber may decrease transit time through the gastrointestinal tract. Research studies traditionally use radio-opaque markers to determine gastric emptying, colonic transit, and whole gut transit time. The SmartPill is a single use pill that can be used to determine gastric emptying, colonic transit, and whole gut transit time without requiring X-rays or fecal collections. Previous studies have found radio-opaque markers and the SmartPill detect the similar transit times.

The purpose of this pilot study is to determine if the SmartPill can detect a change in transit time using a significant dose of dietary fiber.

The ability of a device to track gastrointestinal transit time, including gastric emptying time, was measured in healthy people consuming low and high fiber diets.

Inclusion Criteria:

• Healthy men and women
• Age 18 - 65
• Non-smoking
• Not taking medication
• Non-dieting
• BMI 18-30
• English literacy
• Ability to swallow the SmartPill

Exclusion Criteria:

• Do not regularly consume breakfast
• Food allergies to ingredients fond in study products
• Dislike of hot cereal
• BMI <18 or >30
• Are not weight stable
• Diagnosed with diabetes, cardiovascular, renal, or hepatic disease
• Cancer in previous 5 years (except basal cell carinoma of the skin)
• Any gastrointestinal disease or condition
• Any gastrointestinal surgeries that alter motility
• Recent antibiotic usage (< 6 months)
• recent or concurrent participation in an intervention research study
• History of drug or alcohol abuse in prior 6 months
• Use of laxatives, anti-diarrheal, antacids, or medications which alter motility
• Vegetarians
• People who eat more than approximately 15 grams of fiber per day
• Currently consume fiber supplements
• Women who are pregnant or lactating
• Women with irregular menstrual cycles