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The purpose of this study is to determine the HIT-antibody generation without prior heparin-exposure in patients undergoing orthopedic surgery.
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| Measure | Description | Time Frame |
|---|---|---|
| incidence of HIT-antibodies | between day 5 and day 14 after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| thromboembolic events | up to 21 days after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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Patients in a primary care clinic undergoing orthopedic surgery without heparin exposure
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marc Schindewolf, MD | Contact | +49 (0)69-6301 | 5096 | marcschindewolf@yahoo.com |
| Edelgard Lindhoff-Last, Prof. | Contact | +49 (0)69-6301 | 5096 | Lindhoff-Last@em.uni-frankfurt.de |
| Name | Affiliation | Role |
|---|---|---|
| Marc Schindewolf, MD | J.W. Goethe University-Hospital Frankfurt/M. | Principal Investigator |
| Edelgard Lindhoff-Last, Prof. | J.W. Goethe-University Hospital Frankfurt/M. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| J.W.Goethe University Hospital Frankfurt/M. | Recruiting | Frankfurt am Main | Hesse | 60590 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18612559 | Background | Schindewolf M, Lindhoff-Last E. Fondaparinux-related thrombocytopenia in a patient with former HIT. Response to Rota et al. (Thromb Haemost 2008; 99: 779-781). Thromb Haemost. 2008 Jul;100(1):168-9; author reply 169-70. doi: 10.1160/TH08-04-0222. No abstract available. | |
| 18589060 | Background | Warkentin TE, Makris M, Jay RM, Kelton JG. A spontaneous prothrombotic disorder resembling heparin-induced thrombocytopenia. Am J Med. 2008 Jul;121(7):632-6. doi: 10.1016/j.amjmed.2008.03.012. |
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| ID | Term |
|---|---|
| D013927 | Thrombosis |
| ID | Term |
|---|---|
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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serum citrated blood edta blood
| 18513213 | Background | Jay RM, Warkentin TE. Fatal heparin-induced thrombocytopenia (HIT) during warfarin thromboprophylaxis following orthopedic surgery: another example of 'spontaneous' HIT? J Thromb Haemost. 2008 Sep;6(9):1598-600. doi: 10.1111/j.1538-7836.2008.03040.x. Epub 2008 May 29. No abstract available. |