The study propose to measure the inflammation level in type 1 diabetes children with the cytokine analysis compared to non diabetic children of the same sibling and to healthy children.

The increase of type 1 diabetes incidence, particularly in young children leads to conduce new diagnostic and therapeutic strategies, notably for associated chronic morbidity.Measurement of chronic inflammation, with modification of the balance between pro-inflammatory cytokines and anti-inflammatory cytokines, could lead to detect patients with high risk to diabetes chronic morbidity.

After parental consent, blood sampling will be carried out by micromethod for cytokine (500 µl) and CRPhs dosages and glycemia (100 µl) and glycated hemoglobin (1 µl). Urine will be collected (50 ml) in the morning for further researches.

Inclusion Criteria:

Type 1 diabetes children group :

• Children aged 2 to 17 years
• Type 1 diabetes children

Controlled group :

• Children aged 2 to 17 years
• Brother or sister of type 1 diabetes children

Exclusion Criteria:

• Per os or inhaled corticoid in the previous month of inclusion
• Acute infectious disease in the previous week of inclusion
• Other chronic disease than diabetes type1

60 children in type 1 diabetes group and 30 children in control group