High-sensitivity C-reactive Protein and United Kingdom Prospective Diabetes Study (UKPDS) Risk Score in Type 2 Diabetes

High-sensitivity C-reactive Protein and UKPDS Risk Score in Type 2 Diabetes: Nalysis With 18F-Fluorodeoxyglucose Positron Emission Tomography

The UKPDS risk score is recommended to assess global risk for future coronary heart disease (CHD) events in primary prevention. Recently, high-sensitivity C-reactive protein (hsCRP) has emerged as a strong independent risk factor for CHD. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising imaging technique for the evaluation of vascular inflammation that reflects vulnerable atherosclerotic plaque.

Inclusion Criteria:

• Type 2 diabetes

Exclusion Criteria:

• Myocardial infarction, unstable angina, stroke, peripheral artery disease, or cardiovascular revascularization
• Resting blood pressure ≥160/100 mmHg
• Malignancy, or severe renal or hepatic disease
• Participants were free of any lipid-lowering therapies and postmenopausal hormone replacement therapy at least the 6 month period prior to enrollment
• History of inflammatory condition or those taking medications that might affect inflammatory status within 6 months