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| Name | Class |
|---|---|
| Ministry of Scientific Research and Information Technology, Poland | OTHER_GOV |
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The study is planned to show whether monotherapies or combined hypolipemic therapy influence the fasting plasma glucose, serum adipokines (leptin, adiponectin, resistin) and proinflammatory cytokines (interleukin-6, TNF alpha) during 30 and 90 day course.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Atorvastatin | Experimental | 10mg of Atorvastatin |
|
| Fenofibrate | Experimental | 267mg of Fenofibrate |
|
| Fenofibrate and atorvastatin | Experimental | 10mg of Atorvastatin and 267mg of fenofibrate |
|
| Therapeutic Lifestyle Change | Placebo Comparator | Placebo and Therapeutic Lifestyle Change |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| To compare monotherapies and combined therapy with each other | Drug | Each patient received two tablets per day. Time interval between pills - 12 hours. In monotherapies patients received one active tablet and one placebo, in combined treatment both pills were active and in placebo group patients taken two placebo tablets |
| Measure | Description | Time Frame |
|---|---|---|
| Adipokines | Serum concentration of leptin, adiponectin and resistin on Day 90 of the treatment. | Day 90 |
| Measure | Description | Time Frame |
|---|---|---|
| Proinflammatory cytokines | Interleukin-6 and TNF alpha serum concentration on the Day 30 of the treatment | Day 30 |
| Adipokines | Serum concentration of leptin, adiponectin and resistin on Day 30 of the treatment. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pharmacology | Katowice | Silesian Voivodeship | 40-762 | Poland |
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| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| ID | Term |
|---|---|
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D011616 | Psychotherapy, Multiple |
| ID | Term |
|---|---|
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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|
| Day 30 |
| Proinflammatory cytokines | Interleukin-6 and TNF alpha serum concentration on the Day 90 of the treatment | Day 90 |