Temporal Pattern of Circulating DNA for Patients Receiving Irradiation

Temporal Pattern of Circulating DNA for Patients Receiving Total Body Irradiation

The purpose of the research study is to test a measurement tool that will determine the radiation dose people receive when they have been accidentally exposed to radiation. This test will be done using a small amount of blood and known dose of radiation.

Inclusion Criteria:

• Patient must be scheduled to undergo Total Body Irradiation (TBI) as part of a conditioning regime for a Bone Marrow Transplant. OR, Be scheduled to undergo Radiation Therapy treatment for a malignancy or other disease and have a radiation treatment field that contains at least 2 liters of tissue receiving at least 2 Gy radiation dose over the first 5 days of treatment.
• Patient must be willing to have blood draws as defined below.
• Patient must provide study-specific informed consent prior to study entry.
• Hemoglobin≥8.
• Age ≥ 18, but not older than age 60.

Exclusion Criteria:

• Patients not meeting the above inclusion criteria.