First In Human Study Of Increasing Oral Doses Of PF-04634817

A Double Blind, Randomized, Placebo Controlled, Dose Escalation Study To Investigate The Pharmacokinetics (In The Fed And Fasted State), Safety And Toleration Of Single Oral Doses Of PF-04634817 In Healthy Volunteers

The study will evaluate the hypothesis that at doses and plasma concentrations which affect pharmacodynamic markers of activity at the chemokine receptors, CCR2 and CCR5, the compound is safe and well tolerated. It will also evaluate the hypothesis that the pharmacokinetic profile is robust and consistent with a once or twice a day therapeutic administration.

Inclusion Criteria:

• Healthy male or female (of non-child bearing potential) subjects between 18 and 55 years of age.
• Body mass index of 17.5 to 30.5 kg/m2 and total body weight > 50kg.

Exclusion Criteria:

• Evidence or history of any clinically significant disease.
• Treatment with an investigational drug within 30 days of study start
• Use of prescription and non-prescription medicines within 7 days of study start