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| Name | Class |
|---|---|
| Göteborg University | OTHER |
| Boston University | OTHER |
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The purpose of this study is to test combined effects of scaling and root planing with periodontal surgery, systemically administered amoxicillin and metronidazole, and/or local tetracycline on pocket depth reduction and attachment level "gain" in patients with chronic periodontitis.
In this 2x2x2 factorial design study, 229 moderate to advanced chronic periodontitis patients stratified according to current smoking status were recruited in USA and Sweden. Patients were randomly assigned to 8 groups, all of which were treated by SRP plus none, one, two or three adjunctive treatments. Thus, patients were assigned to groups that did or did not receive Surg, LAb, SAb or LAb+SAb (All) providing 8 treatment combinations (Surg + All, Surg + SAb, Surg + LAb, Surg alone, SRP + All, SRP + SAb, SRP + LAb, SRP alone). Clinical, microbiological and immunological measurements were taken for 2 years (at baseline, 3, 6, 12, 18 and 24 months). To focus on changes diseased sites, analysis was restricted to sites with baseline pocket depth greater than 5 mm. (also, these were the only sites treated by LAb). In this report, main effects and interactions were evaluated for PD reduction and AL gain two years post therapy for 187 of patients. Mean values were computed for each treatment group and averages after 2 years were compared to baseline by ANOVA. Factorial ANCOVA was used to examine significance of differences between Surg or not, SAb or not and LAb or not for PD reduction and AL gain using baseline attachment level or pocket depth as covariates and including current smoking as a factor.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Scaling and root planing | Active Comparator | scaling and root planing as a solo therapy |
|
| Periodontal surgery | Experimental |
| |
| systemic antibiotics | Experimental |
| |
| Local delivery of tetracycline | Experimental |
| |
| local antibiotic and systemic antibiotics | Experimental |
| |
| local antibiotics and surgery | Experimental |
| |
| systemic antibiotics and surgery | Experimental |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| scaling and root planing | Other | scaling and root planing as a single therapy |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Attachment Level Gain | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Probing pocket depth reduction | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| J Max Goodson, DDS, PhD | The Forsyth Institute | Principal Investigator |
| Anne D Haffajee, BDS | The Forsyth Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Forsyth Institute | Boston | Massachusetts | 02115 | United States |
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| local and systemic antibiotics and surgery | Experimental |
|
| local tetracycline |
| Drug |
local delivery of tetracycline fibers releasing approximately 1.7 mg/tooth in all pockets >5mm |
|
| systemic metronidazole and amoxicillin | Drug | systemic metronidazole (250 mg tid x 14) and amoxicillin (500 mg bid x 14 |
|
| surgery | Other | periodontal surgery in residual pockets of >4mm |
|
| local antibiotics and systemic metronidazole and amoxicillin | Drug | 1.7 mg/tooth tetracycline fiber plus metronidazole (250 mg tid x14d)and amoxicillin (500 mg bid x 14d) |
|
| local tetracycline and periodontal surgery | Other | local delivery of tetracycline fibers releasing approximately 1.7 mg/tooth in all pockets >5mm and periodontal surgery in residual pockets of >4mm |
|
| periodontal surgery and systemic metronidazole and amoxicillin | Other | surgery in residual pockets >4mm and metronidazole (250mg tidx14d) and amoxicillin (500mg bidx14d) |
|
| surgery, local tetracycline, systemic metronidazole and amoxicillin | Other | periodontal surgery in residual pockets >4mm, tetracycline ibers releasing approximately 1.7 mg/tooth in pockets >5mm, systemic metronidazlo (250mg tidx14d) and amoxicillin (500 mg bidx14d) |
|
| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D055113 | Chronic Periodontitis |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D014080 | Tooth Exfoliation |
| D016745 | Root Planing |
| D000658 | Amoxicillin |
| D013514 | Surgical Procedures, Operative |
| ID | Term |
|---|---|
| D009063 | Dental Physiological Phenomena |
| D055688 | Digestive System and Oral Physiological Phenomena |
| D012534 | Dental Scaling |
| D003777 | Dental Prophylaxis |
| D010517 | Periodontics |
| D003813 | Dentistry |
| D013357 | Subgingival Curettage |
| D011313 | Preventive Dentistry |
| D000667 | Ampicillin |
| D010400 | Penicillin G |
| D010406 | Penicillins |
| D047090 | beta-Lactams |
| D007769 | Lactams |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013457 | Sulfur Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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