The purpose of this study is to compare outcome of high risk myelodysplasia patients aged from 50 to 70 years with or without HLA compatible (9 or 10 identities / 10) donor. High risk myelodysplasia includes IPSS intermediate 2 and high myelodysplasia and patients with sever thrombocytopenia. Patients are registered when they acquire risk factors.

Inclusion Criteria:

• 50 to 70 years

• For myelodysplasia other than CMML: patients can be included if they have at least one of these criteria:

  1. IPSSintermediate 1 and poor cytogenetics (complex, 3 or 7 abnormality);
  2. thrombopenia < 20x10ex9/L:
  3. IPSS intermediate 2 or high

• For CMML: patients can be included if they have at least one of these criteria:

  1. 2 of these criteria: hyperleucocytosis > 10x10exp9/L, splenomegaly>18cm, hemoglobin < 10gr/dl, platelet < 100x10ex9/L
  2. IPSS intermediate 2 or high

Exclusion Criteria:

• Patient not eligible for transplantation (including patients without donor)because of severe co-morbidity including:
• Renal failure with creatinine clearance < 30ml/min
• Cirrhosis or hepatic failure
• Respiratory disease with vital capacity < 30%
• Uncontrolled cardiac failure
• Uncontrolled neurological disease
• Poor performance status with karnofsky < or = 60%

Patients from 50 to 70 years with high risk myelodysplasia and eligible for transplantation