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| Name | Class |
|---|---|
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
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Background: Body weight supported (BWS) locomotor training improves overground walking ability in individuals with motor-incomplete spinal cord injury (SCI). While there are various approaches available for locomotor training, there is no consensus regarding which of these is optimal. The purpose of this ongoing investigation is to compare outcomes associated with these different training approaches.
Subjects and Methods: Subjects with chronic motor-incomplete SCI have completed training and initial and final testing. Subjects were randomly assigned to 1 of 4 different BWS assisted-stepping groups, including: 1) treadmill training with manual assistance (TM), 2) treadmill training with stimulation (TS), 3) overground training with stimulation (OG), or 4) treadmill training with robotic assistance (LR). Prior to and following participation the investigators assessed:
Hypotheses:
In individuals with incomplete spinal cord injury (SCI):
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treadmill training - manual assist (TM) | Active Comparator | Participants in the TM group received partial body weight support unilateral or bilateral manual assistance from a trainer for stepping |
|
| Treadmill training - electrical stimulation (TS) | Active Comparator | Participants in the TS group received partial body weight support and bilateral functional electrical stimulation to assist stepping |
|
| Overground Training (OG) | Active Comparator | Training over ground with body weight support and electrical stimulation for dorsiflex assistance |
|
| Treadmill training - locomat robot (LR) | Active Comparator | Treadmill training with partical body weight support and assistance of a robotic gait orthosis for stepping |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Locomotor training | Other | Locomotor training using body weight support with training on a treadmill or training over ground with differing forms of assistance for stepping |
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| Measure | Description | Time Frame |
|---|---|---|
| Walking speed | Walking speed collected during 10-Meter Walk Test | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Functional walking capacity | Distance walked in timed 2-Minute Walk Test | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Edelle C Field-Fote, PT, PhD | University of Miami | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16398945 | Result | Field-Fote EC, Lindley SD, Sherman AL. Locomotor training approaches for individuals with spinal cord injury: a preliminary report of walking-related outcomes. J Neurol Phys Ther. 2005 Sep;29(3):127-37. doi: 10.1097/01.npt.0000282245.31158.09. | |
| 17046161 | Result | Field-Fote EC, Brown KM, Lindley SD. Influence of posture and stimulus parameters on post-activation depression of the soleus H-reflex in individuals with chronic spinal cord injury. Neurosci Lett. 2006 Dec 13;410(1):37-41. doi: 10.1016/j.neulet.2006.09.058. Epub 2006 Oct 12. |
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| 17475549 | Result | Field-Fote EC, Dietz V. Single joint perturbation during gait: preserved compensatory response pattern in spinal cord injured subjects. Clin Neurophysiol. 2007 Jul;118(7):1607-16. doi: 10.1016/j.clinph.2007.03.022. Epub 2007 May 1. |
| 19648013 | Result | Ness LL, Field-Fote EC. Whole-body vibration improves walking function in individuals with spinal cord injury: a pilot study. Gait Posture. 2009 Nov;30(4):436-40. doi: 10.1016/j.gaitpost.2009.06.016. Epub 2009 Aug 3. |
| 19799783 | Result | Nooijen CF, Ter Hoeve N, Field-Fote EC. Gait quality is improved by locomotor training in individuals with SCI regardless of training approach. J Neuroeng Rehabil. 2009 Oct 2;6:36. doi: 10.1186/1743-0003-6-36. |
| 27901413 | Derived | Sandler EB, Roach KE, Field-Fote EC. Dose-Response Outcomes Associated with Different Forms of Locomotor Training in Persons with Chronic Motor-Incomplete Spinal Cord Injury. J Neurotrauma. 2017 May 15;34(10):1903-1908. doi: 10.1089/neu.2016.4555. Epub 2017 Jan 4. |
| D014947 | Wounds and Injuries |