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| ID | Type | Description | Link |
|---|---|---|---|
| R01AG034639 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
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Cognitive aging and cognitive decline are important public health concerns in an aging US population. The investigators will conduct a randomized controlled trail among healthy older adults to assess effects of several innovative activities on remediation of age-related cognitive decline.
ACE-Seniors is designed as a single-site trial of four randomly assigned interventions, Tai Chi exercise, autobiographical writing, both Tai Chi and autobiography (dual intervention), and general health education. Participants are relatively healthy adults aged 70 years or older, who are not regular practitioners of Tai Chi or regular writers. They are without medical or neurological disorders that would substantially limit the ability to participate in study interventions, without dementia or mild cognitive impairment, relatively sedentary, able to walk unassisted, and able to score 4 or better on the Short Physical Performance Battery. Interventions are administered over a 6 month period of time, with similar exposure times among the four groups. The prespecified primary endpoint is derived from a composite neuropsychological measure, based on three tests of executive function and three tests of episodic memory. The planned sample size is 96 (24 per group). Intention-to-treat analysis will include all eligible participants who complete baseline assessments.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tai Chi | Experimental | Tai Chi exercises |
|
| Guided autobiography | Experimental | Autobiographical writing during class sessions and at home |
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| Qigong | Experimental | Qigong exercises (exploratory, not part of the original protocol, added to gain experience with this intervention) |
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| Successful aging | Active Comparator | Seminars on the theme of successful aging |
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| Combination | Experimental | Combination of Tai Chi exercises and autobiographical writing |
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| Comparison | Placebo Comparator | No assigned experimental activity (exploratory, not part of the original protocol, added to gain experience with a placebo comparator) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tai Chi | Behavioral | Tai Chi classes and exercises |
| |
| Guided autobiography |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive (executive function and episodic memory) | 6 and 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Other cognitive measures | 6 and 12 months | |
| Physical performance and other non-cognitive measures | 6 and 12 months | |
| Adherence and retention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dr Victor Henderson | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University School of Medicine | Stanford | California | 94305 | United States |
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| ID | Term |
|---|---|
| D026302 | Tai Ji |
| D064906 | Qigong |
| ID | Term |
|---|---|
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026241 | Exercise Movement Techniques |
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|
| Behavioral |
Autobiographical writing in class and at home |
|
| Qigong | Behavioral | Qigong classes and exercises (exploratory) |
|
| Successful aging | Behavioral | Seminar series on the theme of successful aging |
|
| Combination | Behavioral | Combination of Tai Chi exercises and autobiographical writing |
|
| Comparison | Behavioral | No assigned behavioral activity (exploratory) |
|
| 6 and 12 months |
| D026741 |
| Physical Therapy Modalities |
| D001945 | Breathing Exercises |