Ondansetron Plus Dexamethasone With or Without Metoclopramide as Antiemetic Prophylaxis After Receiving Cisplatin

Randomized, Placebo-controlled Trial of Ondansetron Plus Dexamethasone With or Without Metoclopramide as Antiemetic Prophylaxis in Patients Receiving High Dose Cisplatin in Routine Medical Practice

The objective of this study is to assess the efficacy and tolerability of metoclopramide added to standard antiemetic regimen for prophylaxis of cisplatin-induced emesis.

Ondansetron plus dexamethasone are standard emetic prophylactic agents for highly emetogenic chemotherapy. Metoclopramide is a dopamine antagonist, which may enhance efficacy of ondansetron and dexamethasone.

Inclusion Criteria:

• schedule to receive first cycle of cisplatin > 50 mg/m^2
• pathologically or histologically confirmed solid cancer
• more than 18 years old
• creatinine clearance more than 50 ml/min
• aminotransferase less than 2 times of upper normal limit

Exclusion Criteria:

• pregnant woman
• patients with episode of vomiting within 24 hours prior to chemotherapy session
• gut obstruction
• brain metastasis
• abdominal or pelvic irradiation
• no history of allergy to study drugs