Study of Vitamin D and Effect on Heart Disease and Insulin Resistance

The Effect of Vitamin D Supplementation on Endothelial Function, Inflammation and Insulin Resistance in HIV

The purpose of this study is to evaluate how Vitamin D affects endothelial function, inflammation, lipids, insulin resistance, vitamin D levels, and parathyroid hormone (PTH).

Randomized placebo controlled trial of vitamin D supplementation in HIV infected subjects with vitamin D deficiency

Inclusion Criteria:

• HIV infected
• HIV-RNA < 400 copies/ml at study entry and for 12 wks. prior
• 25-hydroxyvitamin D level <20
• On a stable anti-retroviral (ARV) regimen for at least 12 weeks prior to study entry

Exclusion Criteria:

• Pregnancy or Breast Feeding
• Diabetes
• Creatinine Clearance <50
• Any active infectious or inflammatory condition
• aspartate aminotransferase (AST) or alanine aminotransferase (ALT) >2.5 within 6 months prior to study entry