Safety of Phenylephrine for Oral Mucositis Prevention

A Phase I Safety Study of Phenylephrine Applied Topically to the Oral Mucosa in Cancer Patients Receiving Radiation to Sub-mandibular Lymph Nodes

The purpose of this study is to determine if applying the drug phenylephrine to the inside of the mouth can be done safely and is tolerable to use in cancer patients receiving radiation to the Sub-mandibular lymph nodes.

Inclusion Criteria:

• cancer patients scheduled to receive at least 5 weeks of radiation therapy to the sub-mandibular lymph nodes
• normal ECG
• normal blood pressure

Exclusion Criteria:

• untreated cardiac disease
• connective tissue disorders
• open sores, wound, ulcerations to oral cavity
• allergy to phenylephrine
• know untreated hypertensin
• abnormal ECG in past 6 months
• taking prescription monoamine oxidase inhibitor (MAOI)
• are pregnant