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The present study is part of an international program and deals with the translation and validation program for the Italian version of the MDS-UPDRS.
The program will be articulated in three steps:
The IRIS protocol deals with phase II and III of the program.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rating Scale administration | Other | Movement Disorder Society_Unified Parkinson's Disease Rating Scale will be submitted to the patient (with the help of the caregiver) in a single visit lasting about 40 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Phase II: To test the appropriateness of the Italian translation and clear understanding of potentially cultural-sensitive items. To refine the translation, if necessary, prior to validation testing. | 6 months | |
| Phase III: the primary outcome of phase III is to confirm factorial analysis of the Italian version against the factor structure of the English version, by each of the four sections of the scale. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| The secondary outcome is to determine the Differential Item Function (DIF) which will be run on items by gender, race , disease severity, education and age. | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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Native Italian-speaking PD patients ranging from mild to severe
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Silvia Campanella, Dr | Contact | +39 02 34535088 | 31 | campanella@mcr-med.com |
| M.Cristina Jori, Dr. | Contact | +39 02 34535088 | 23 | jori@mcr-med.com |
| Name | Affiliation | Role |
|---|---|---|
| Paolo Barone, Prof. | Universita' Federico II di Napoli | Principal Investigator |
| Maurizio Zibetti, Dr | Azienda Sanitaria Ospedaliera "San Giovanni Battista di Torino" Le Molinette | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universita' Federico II di Napoli | Naples | 80131 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | S. Fahn et al: The Unified Rating Scale for Parkinsonism. In Fahn, Marsden, Jenner, Teychenne eds.: Recent Developments in Parkinson's disease. N.J. Macmillan Healthcare Information: 153-63, 1987 | ||
| 12815652 | Background | Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease. The Unified Parkinson's Disease Rating Scale (UPDRS): status and recommendations. Mov Disord. 2003 Jul;18(7):738-50. doi: 10.1002/mds.10473. | |
| 17115387 |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Angelo Antonini, Prof | Ospedale San Camillo IRCCS Venezia | Principal Investigator |
| Gianni Pezzoli, Prof | Istituti Clinici di Perfezionamento Milano | Principal Investigator |
| Michele Tinazzi, Prof | Azienda Ospedaliera Universitaria Integrata Verona - Policlinico G.Rossi | Principal Investigator |
| Giovanni Abbruzzese, Prof | Universita' di Genova | Principal Investigator |
| Ubaldo Bonuccelli, Prof | Universita' di Pisa | Principal Investigator |
| Giovanni Fabbrini, Dr | Universita' La Sapienza di Roma | Principal Investigator |
| Letterio Morgante, Prof | Azienda Ospedaliera Universitaria Policlinico G.Martino di Messina | Principal Investigator |
| Mario Zappia, Prof | Azienda Ospedaliero-Universitaria Policlinico Vittorio Emanuele di Catania | Principal Investigator |
| Alberto Albanese, Prof | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | Principal Investigator |
| Claudio Pacchetti | Istituto Neurologico Nazionale Fondazione IRCCS "C. Mondino" di Pavia | Principal Investigator |
| Aldo Quattrone, Prof | Policlinico Universitario Mater Domini di Catanzaro | Principal Investigator |
| Giovanni Cossu, Dr | Azienda Ospedaliera "G. Brotzu" di Cagliari | Principal Investigator |
| Aroldo Rossi, Prof | Universita' degli Studi di Perugia | Principal Investigator |
| Paolo Martinelli, Prof | Universita' di Bologna | Principal Investigator |
| Background |
| Goetz CG, Fahn S, Martinez-Martin P, Poewe W, Sampaio C, Stebbins GT, Stern MB, Tilley BC, Dodel R, Dubois B, Holloway R, Jankovic J, Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Schrag A, Teresi JA, Van Hilten JJ, LaPelle N. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan. Mov Disord. 2007 Jan;22(1):41-7. doi: 10.1002/mds.21198. |
| 19025984 | Background | Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P, Poewe W, Sampaio C, Stern MB, Dodel R, Dubois B, Holloway R, Jankovic J, Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Schrag A, Teresi JA, van Hilten JJ, LaPelle N; Movement Disorder Society UPDRS Revision Task Force. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord. 2008 Nov 15;23(15):2129-70. doi: 10.1002/mds.22340. |
| 18381647 | Background | Pagonabarraga J, Kulisevsky J, Llebaria G, Garcia-Sanchez C, Pascual-Sedano B, Gironell A. Parkinson's disease-cognitive rating scale: a new cognitive scale specific for Parkinson's disease. Mov Disord. 2008 May 15;23(7):998-1005. doi: 10.1002/mds.22007. |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |