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| ID | Type | Description | Link |
|---|---|---|---|
| 2009-012005-19 | EudraCT Number |
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The main objective is to validate the safety and efficacy of intravenous and oral sildenafil in the acute vasodilator test in patients with persistence of, at least, moderate pulmonary hypertension after valvular surgery successfully, with a correct left ventricular function and no valvular disease hemodynamically significant.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sildenafil 20mg oral | Other |
| |
| Sildenafil 10mg intravenous | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sildenafil 20mg oral vs Sildenafil 10mg intravenous | Drug | 2 arms to comparation: Sildenafil 20mg oral vs intravenous Sildenafil 10mg |
|
| Measure | Description | Time Frame |
|---|---|---|
| Effectiveness | The main efficacy parameter is the effect on pulmonary vascular vasodilation quantified as decreased Pulmonary Vascular Resistance. | one day per patient |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Enric Domingo, Promotor | Contact | 00-34-93-2746455 | edrcg@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Enric Domingo, Promotor | Vall Hebron Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vall Hebron Hospital | Recruiting | Barcelona | Barcelona | 08035 | Spain |
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| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D000068677 | Sildenafil Citrate |
| ID | Term |
|---|---|
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013450 | Sulfones |
| D013457 |
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|
| D002318 |
| Cardiovascular Diseases |
| Sulfur Compounds |
| D010879 | Piperazines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |