Montelukast and Inhaled Nasal Steroid Tx in Adult Obstructive Sleep Apnea (OSA)

Montelukast and Nasa ICS for Treatment of Mild Obstructive Sleep Apnea in Adults

In children with mild apnea combined therapy with an inhaled nasal steroid and a medication that decreased nasal congestion (montelukast) was shown to be effective. We are testing to see if this combination works in adults with mild apnea as well.

40 adults with mild OSA (< 5 apneas/hypopneas per hour of sleep) will receive either a combination of two medicines that decrease nasal congestion-montelukast and nasal budesonide-or a placebo pill and nasal spray. After 3 months of therapy, a repeat sleep study will be done to determine the differences, if any, in the frequency of sleep disordered breathing in the two groups.

Inclusion Criteria:

• age 18 - 100 years
• RDI between 5 - 15
• all races
• both sexes

Exclusion Criteria:

• craniofacial, syndromic, neurological abnormalities
• current or previous use of Singular, Rhinocort within last 6 months
• acute upper respiratory infections
• recent nasal trauma, nasal surgery, nasal septum perforation
• known immunodeficiency or under going immunosuppressant therapy
• current therapy with drugs that interact with Montelukast or Budesonide