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| ID | Type | Description | Link |
|---|---|---|---|
| 09-195 | Registry Identifier | Ethik- Kommission zu Lübeck |
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Great scientific effort has been made to improve practical as well as economical procedures of modern assisted reproduction.
In the last years a shift from the well established method of slow-rate freezing to vitrification of 2PN zygotes and embryos could be observed. Like any other method of cryopreservation, the outcome of vitrification will be affected by several factors related to technique itself, its practical management and patient characteristics.
The investigators want to investigate the influence of vitrification on the outcome of of 2PN oocytes, pregnancy and infant health.
A Comparison between a cohort of spontaneous conceived children and children of vitrified and slow- cooled 2PN oocytes is planned.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Spontaneous | Mothers with children conceived after spontaneous cycle |
| |
| Vitrificatíon | Mothers with children conceived after vitrification cycle |
| |
| slow- rate freezing | Mothers with children conceived after slow- rate freezing cycle |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observation | Other | Alberta infant motor scale Griffiths test Kauffmann ABC |
|
| Measure | Description | Time Frame |
|---|---|---|
| Maternal pregancy outcome | spontaneous or operative delivery, birth injuries, conjoined morbidity | 7 years |
| embryo survival | embryo survival rate | 7 years |
| Measure | Description | Time Frame |
|---|---|---|
| infant health | infant vital characteristics (APGAR, arterial cord ph), infant development: only develomental milestones: sitting, standing, walking infant morbidity | 7 years |
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Inclusion Criteria:
Exclusion Criteria:
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tertiary university hospital
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| Name | Affiliation | Role |
|---|---|---|
| Daniel A Beyer, MD | Lübeck University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Schleswig- Holstein University, Campus Lübeck, Department of Reproductive Medicine | Lübeck | Schleswig-Holstein | D-23538 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19458318 | Background | Wennerholm UB, Soderstrom-Anttila V, Bergh C, Aittomaki K, Hazekamp J, Nygren KG, Selbing A, Loft A. Children born after cryopreservation of embryos or oocytes: a systematic review of outcome data. Hum Reprod. 2009 Sep;24(9):2158-72. doi: 10.1093/humrep/dep125. Epub 2009 May 20. | |
| 17579980 | Background | Kagawa N, Kuwayama M, Nakata K, Vajta G, Silber S, Manabe N, Kato O. Production of the first offspring from oocytes derived from fresh and cryopreserved pre-antral follicles of adult mice. Reprod Biomed Online. 2007 Jun;14(6):693-9. doi: 10.1016/s1472-6483(10)60670-0. |
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| ID | Term |
|---|---|
| D019370 | Observation |
| ID | Term |
|---|---|
| D008722 | Methods |
| D008919 | Investigative Techniques |
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| 19490780 | Background | Noyes N, Porcu E, Borini A. Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies. Reprod Biomed Online. 2009 Jun;18(6):769-76. doi: 10.1016/s1472-6483(10)60025-9. |
| 20188356 | Background | Noyes N, Knopman J, Labella P, McCaffrey C, Clark-Williams M, Grifo J. Oocyte cryopreservation outcomes including pre-cryopreservation and post-thaw meiotic spindle evaluation following slow cooling and vitrification of human oocytes. Fertil Steril. 2010 Nov;94(6):2078-82. doi: 10.1016/j.fertnstert.2010.01.019. Epub 2010 Feb 26. |
| 20185513 | Background | Ubaldi F, Anniballo R, Romano S, Baroni E, Albricci L, Colamaria S, Capalbo A, Sapienza F, Vajta G, Rienzi L. Cumulative ongoing pregnancy rate achieved with oocyte vitrification and cleavage stage transfer without embryo selection in a standard infertility program. Hum Reprod. 2010 May;25(5):1199-205. doi: 10.1093/humrep/deq046. Epub 2010 Feb 25. |
| 17359578 | Background | Al-Hasani S, Ozmen B, Koutlaki N, Schoepper B, Diedrich K, Schultze-Mosgau A. Three years of routine vitrification of human zygotes: is it still fair to advocate slow-rate freezing? Reprod Biomed Online. 2007 Mar;14(3):288-93. doi: 10.1016/s1472-6483(10)60869-3. |