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| Name | Class |
|---|---|
| Institut National de la Santé Et de la Recherche Médicale, France | OTHER_GOV |
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It is well known that airway management can be difficult during pregnancy. Increased risks for difficult intubation in pregnant women have been often reported. Thus, pregnancy is regarded as a period of high anesthesiologic risk.
Generalized weight gain is a well known factor influencing the upper airway in pregnant women. However, the modifications of the airway itself are less well documented.
The acoustic reflection method is based on the analysis of the reflection of a single transient planar wave allowing the analysis of the longitudinal cross-sectional area profile of the examined cavity. It is a noninvasive and harmless method.
The aim of the study is to evaluate by acoustic reflection method the physiological modifications of the upper airways during pregnancy.
Women enrolled in the study will undergo an acoustic recording during the first, second, and third trimester of pregnancy, as well as two days and one month after delivery. Forty pregnant women will be included in this monocentric, prospective, open labelled study.
Moreover, a single acoustic recording will be performed in 10 other pregnant women undergoing an MRI for obstetrical purpose. The estimated caliber of the upper airways by MRI and acoustic method will be compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Physiological modifications | Pregnant women who attend the routine ultrasound control in our institution before 14 weeks of pregnancy |
| |
| MRI and acoustic | Women undergoing an MRI for obstetrical purpose |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acoustic reflection method | Device | An acoustic reflection device gives the longitudinal cross-sectional area profile along airways. It is based on the analysis of a planar acoustic wave propagating in a rigid duct connected to airway. |
| Measure | Description | Time Frame |
|---|---|---|
| Physiological modifications during pregnancy and acoustic reflection method | Main aim: to evaluate by acoustic reflection method the physiological modifications of the upper airways during pregnancy. Women enrolled in the study will undergo an acoustic recording during:
| 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| MRI and acoustic reflection method | Secondary aim: a single acoustic recording will be proposed to 10 pregnant women undergoing an MRI for obstetrical purpose. The estimated caliber of the upper airways by MRI and acoustic method will be compared. | 6 months |
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Inclusion Criteria:
Pregnant women who attend the routine ultrasound control in our institution before 14 weeks of pregnancy will be invited to participate in the study.
Women are eligible for the study if they are:
Exclusion Criteria:
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Healthy pregnant women
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| Name | Affiliation | Role |
|---|---|---|
| Brigitte FAUROUX, MD, PhD | Assistance Publique - Hôpitaux de Paris | Study Director |
| Nicolas LEBOULANGER, MD | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Armand Trousseau University Hospital | Paris | 75012 | France | |||
| Hôpital d'Enfants Armand Trousseau |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18292672 | Background | Kodali BS, Chandrasekhar S, Bulich LN, Topulos GP, Datta S. Airway changes during labor and delivery. Anesthesiology. 2008 Mar;108(3):357-62. doi: 10.1097/ALN.0b013e31816452d3. | |
| 11160063 | Background | Louis B, Fodil R, Jaber S, Pigeot J, Jarreau PH, Lofaso F, Isabey D. Dual assessment of airway area profile and respiratory input impedance from a single transient wave. J Appl Physiol (1985). 2001 Feb;90(2):630-7. doi: 10.1152/jappl.2001.90.2.630. |
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| Paris |
| 75012 |
| France |