Impact of Spices and Herbs on Endothelial Function

Investigation of the Impact of Spices and Herbs on Endothelial Function and Other CVD Risk Factors in Men and Women.

The general objective of the study is to investigate the effects of the daily consumption of spices and herbs for four (4) consecutive weeks in endothelial function and cardiovascular risk factors of men and postmenopausal women.

The purpose is to assess whether the polyphenol/antioxidant content of different spices will affect endothelial function and other cardiovascular risk factors.

Inclusion Criteria:

• Age 40-70 yrs
• Men and postmenopausal women
• Waist girth >102cm (men) or >88cm (women)
• LDL-C > 2.8 mmol/L
• Framingham 10-yr risk score < 10%
• Marginal endothelial dysfunction
• Non smoker

Exclusion Criteria:

• Medication for lipid, hypertension, diabetes
• History of CVD, diabetes, other endocrines disorders
• Pre-menopausal women
• Alcohol consumption > 1 drink per day
• Unusual dietary habits (e.g. vegetarism)
• Chronic use of supplements (estrogens, vitamins, minerals or flavonoids)
• Aversion or intolerance for spices and/or herbs
• Injury to fingers or amrs that would interfere with endothelial function measurement