The hypothesis of this study is that tacrolimus reduces the proteinuria in adult patient with minimal change nephritic syndrome.

A pilot study for comparative clinical trial on the therapeutic effect of tacrolimus (Prograf cap®) in adult patient with minimal change nephritic syndrome.

Inclusion Criteria:

• from 18yrs to 80 yrs , man and women
• Minimal change disease is diagnosed by kidney biopsy
• On screening, the patient shows that the level of urine protein/creatinine ratio is over 3.0
• On screening, the patient shows that the serum albumin is below 3.0g/dL
• the patient sign on the concent form

Exclusion Criteria:

• the patient have experience to take tacrolimus or cyclosporin for 1 month
• If it is the relapse of the nephrotic syndrome, before relapse, the maintenance dose of steroid is over 0.3 mg/kg/day
• steroid dependent or steroid resistant or frequent relapse case
• uncontrolled hypertension
• pregnancy or anticipate pregnancy with 6 month
• hypersensitivity to tacrolimus or macrolide
• acute hepatitis or the level of AST or ALT is over 2 times of normal range or the level of bilirubin is over 2.0 mg/dL