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| Name | Class |
|---|---|
| Santa Casa de Misericórdia de Belo Horizonte | OTHER |
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This study evaluates the use of dexmedetomidine or chloral hydrate for sedation during electroencephalography in patients with neurological disorders. The hypothesis is that this drugs provides similar changes in EEG pattern.
Patients with chronic neurological disorders such as cerebral palsy or autism need to be sedated during electroencephalography (EEG). However, various sedatives and hypnotics affect the outcome of the review and is not shown. Chloral hydrate (CH) is widely used in children, but in this patients it is less effective.Recently, dexmedetomidine (DEX) has been tested because preliminary data suggests that this drug does not affect the EEG. The aim of the present work was to compare the electroencephalogram (EEG) pattern during CH or DEX sedation, to test the hypothesis that both drugs exert similar effects in EEG.Seventeen patients were evaluated during sedation with DEX or CH on separate occasions.The EEG was subjected to qualitative and quantitative analysis. Clinical variables were also compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dexmedetomidine, chloral hydrate | Other | sedation with dexmedetomidine or chloral hydrate on separate occasions in the same patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | 1 μg kg-1 infused in 10 min, and thereafter maintained from 0.2 to 0.7 μg kg-1 h- 1 |
|
| Measure | Description | Time Frame |
|---|---|---|
| electroencephalogram pattern | Qualitative analysis: identification of the deepest phase of sleep achieved during the examination, evaluation of background activity (normal, fast activity increased or slow activity increased). Quantitative analysis: density, duration, and amplitude of sleep spindles, spectral power and dominant frequence. | twenty minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Effective sedative | Maintain adequate sedation permitting the completion of the examination | twenty minutes |
| Adverse effects | Incidence of bradycardia, hypotension, respiratory complications and vomiting |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Magda Fernandes | Santa Casa de Misericórdia de Belo Horizonte | Principal Investigator |
| Gomez Renato | Federal University of Minas Gerais | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Santa Casa de Belo Horizonte | Belo Horizonte | Minas Gerais | 30150-221 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19589455 | Background | Lubisch N, Roskos R, Berkenbosch JW. Dexmedetomidine for procedural sedation in children with autism and other behavior disorders. Pediatr Neurol. 2009 Aug;41(2):88-94. doi: 10.1016/j.pediatrneurol.2009.02.006. | |
| 18005372 | Background | Huupponen E, Maksimow A, Lapinlampi P, Sarkela M, Saastamoinen A, Snapir A, Scheinin H, Scheinin M, Merilainen P, Himanen SL, Jaaskelainen S. Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep. Acta Anaesthesiol Scand. 2008 Feb;52(2):289-94. doi: 10.1111/j.1399-6576.2007.01537.x. Epub 2007 Nov 14. |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D002697 | Chloral Hydrate |
| D012996 | Solutions |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Chloral Hydrate | Drug | Initial dose=50 mg/kg |
|
|
| Two hours |
| D005026 |
| Ethylene Glycols |
| D006018 | Glycols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D004364 | Pharmaceutical Preparations |