Resistant Arterial Hypertension Cohort Study

Interventional Prospective Cohort Study, Multi-center With Nested Case-control Studies (Family-based and Non-family Based) on Individuals With Resistant Arterial Hypertension.

The purpose of this study is to investigate the epidemiology of resistant hypertension, evaluate the efficacy and feasibility of a standardized drug treatment regimen (including the randomization of two doses of the diuretic used - chlorthalidone), study two interventions in the group of patients that is non-compliant, and study environmental and genetic variables of individuals with resistant hypertension in a family design.

Inclusion Criteria:

• informed consent
• resistant hypertension at the moment of inclusion
• 18 years or more, both sexes are included
• women at reproductive age: consenting to use oral contraception

Exclusion Criteria:

• patients mentally impaired or unable to give informed consent
• patients speaking only a foreign language other than French, German, or English
• patients living far away, making the study visits not practical