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The purpose of this study is to test whether prostacyclin analogues' cathodal iontophoresis induce a cutaneous vasodilation in healthy volunteers's forearm, without local side effects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treprostinil | Experimental | Treprostinil iontophoresis (250, 25 and 2.5 microM) |
|
| Iloprost | Experimental | Iloprost iontophoresis (200, 20 and 2 microM) |
|
| NaCl 0.9% | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| treprostinil | Drug | Cutaneous iontophoresis at 20 microA/ 100 microA during 20 min |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Amplitude of forearm cutaneous vasodilatation assessed using laser Doppler imaging | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Local tolerance assessed clinically | Day 0 and after 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Unité de Pharmacologie Clinique, Inserm CIC3, CHU Grenoble | Grenoble | 38043 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23400744 | Derived | Blaise S, Roustit M, Hellmann M, Millet C, Cracowski JL. Cathodal iontophoresis of treprostinil induces a sustained increase in cutaneous blood flux in healthy volunteers. J Clin Pharmacol. 2013 Jan;53(1):58-66. doi: 10.1177/0091270011434352. Epub 2013 Jan 24. |
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| ID | Term |
|---|---|
| C427248 | treprostinil |
| D016285 | Iloprost |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D011465 | Prostaglandins, Synthetic |
| D011453 | Prostaglandins |
| D015777 | Eicosanoids |
| D005231 | Fatty Acids, Unsaturated |
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| iloprost |
| Drug |
Cutaneous iontophoresis at 20 microA/ 100 microA during 20 min |
|
| NaCl 0.9% | Drug | Cutaneous iontophoresis at 20 microA/ 100 microA during 20 min |
|
| D005227 |
| Fatty Acids |
| D008055 | Lipids |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |