Effect of Deep Brain Stimulation on Gastrointestinal (GI) Motility

Effect of Deep Brain Stimulation on Voluntary and Involuntary Gastrointestinal Motility in Parkinson's Disease

Parkinson's disease is characterized by extra-pyramidal symptoms as well as digestive involvement with gastrointestinal motility (GI) impairment. Deep brain stimulation has been recently developed as a successful treatment for extrapyramidal symptoms. In addition, preliminary reports suggest that this therapy might be successful to relieve GI symptoms as well. The aim of this study is therefore to assess the effect of deep brain stimulation on GI voluntary as well as involuntary motility.

Inclusion Criteria:

• patient over 18 yo
• patient with Parkinson's disease implanted for deep brain stimulation
• patient responders to deep brain stimulation (UPDRS improved by at least 40%)
• patient covered by the french health care system
• patient not taking anti-parkinsonian medication the day before evaluation
• French speaking

Exclusion Criteria:

• patient below 18 yo
• pregnancy
• Severe psychiatric or cognitive disorders
• diabetes mellitus
• morbid obesity
• compulsive eating disorders
• diffuse GI motility impairment (except Parkinson's disease)
• other evolutive neurologic disorders
• previous history of significant GI resection
• inability to swallow or defecate when asked