Daptomycin as Antibiotic Prophylaxis of Sternal Wound Infections

Prospective Randomised Study of Daptomycin as Antibiotic Prophylaxis of Sternal Wound Infections After Median Sternotomy

The purpose of this study is to show that the incidence of sternal wound infections at day 30 after cardiac surgery is 50% lower with the additional use of Daptomycin on top of a standard antibiotic prophylaxis as compared to the standard antibiotic prophylaxis alone.

Inclusion Criteria:

• age between 18-80
• written informed consent (IC)

Exclusion Criteria:

• pregnant and lactating women
• patients operated for a transplantation
• patients with a increased myopathy risk
• patients with a creatinine clearance < 30ml/min; patients on hemodialysis
• patients after a previous sternotomy
• treatment with any antibiotics 14 days prior study start
• treatment with Daptomycin or Cefuroxime within 3 month prior study start