This is an observational, prospective, non-interventional, non-randomised, open label multicentric study planned to be conducted in 1000 subjects with mild to moderate primary hypertension in approximately 20 centres in Thailand. The purpose of this study is to examine the beneficial effects of combination of bisoprolol with hydrochlorothiazide available as Lodoz in treatment of Thai subjects with mild to moderate hypertension. The outcome of the study would also provide information on the optimal daily dosage schedule as well as adherence of Lodoz.

Essential hypertension is a heterogenous multifactorial disease affecting large number of population. Monotherapy treatment in hypertension is often unable to achieve the desired blood pressure (BP) goals and subjects even remain at significant risk for developing cardiovascular disease. The use of combination therapy as first line treatment for hypertension provides a solution to the management problems related to hypertension. Among combination drugs, low dose combinations are useful tools in treating large segments of hypertensive subjects because of their several advantages, such as simplified dosage regimens, improve compliance and hypertensive control, decrease dose dependent side effects as well as reduce costs.

OBJECTIVES

Primary objective:

• To evaluate the efficacy of Lodoz therapy when used in routine clinical practice in subjects with mild to moderate essential hypertension.

Secondary objective:

• To evaluate the discontinuation rate of Lodoz therapy.

Inclusion Criteria:

• Signed written informed consent
• Subjects diagnosed with mild to moderate essential hypertension
• Subjects foreseen for Lodoz treatment for hypertension
• Age ≥ 18 years

Exclusion Criteria:

• Subjects treated with Lodoz before study initiation
• Subjects who are pregnant
• Subjects with any known contraindications to Lodoz based on local label

Residents of Thailand diagnosed with mild to moderate essential hypertension.