The Chloroquine for Influenza Prevention Trial

A Randomised, Double-blind, Placebo Controlled Trial of Chloroquine for the Prevention of Influenza

A randomised controlled trial to determine the efficacy of chloroquine for the prevention of influenza

Inclusion Criteria:

• Age 18 -65
• Have the ability to provide informed consent
• If a woman of child-bearing potential, willing to use contraception for the period of the trial

Exclusion Criteria:

• Acute influenza-like illness at screening
• History of psoriasis, porphyria cutanea tarda, epilepsy, myasthenia gravis, myopathy of any cause, cardiac arrhythmias, or serious hepatic or renal disease
• Pregnancy or breast feeding
• Current use of medication with known serious hepatotoxic effects
• Current use of medication with known serious interaction with CQ: amiodarone, anticonvulsants, ciclosporin, digoxin, mefloquine, moxifloxacin
• Current severe depression (as indicated by current use of antidepressant medication)
• Known serious retinal disease
• Current or recent (within the past 30 days) participation in any other clinical intervention trial.
• Known G6PD deficiency
• Vaccination for influenza (seasonal or H1N1 strain) within the 3 months prior to screening