Prospective, Multicenter Non Interventional Study to Evaluate Adherence to Betaferon Over a 2 Years Period

Prospective Multicenter, Non Interventional Study to Evaluate the Patient's Characteristics Associated With Adherence to Treatment Regimen by Betaferon in the BetaPlus Program

The aim of the SEPLUS study is to evaluate the patients characteristics associated with adherence to Betaferon over a 24-month follow up period after the initiation of Betaferon in the BetaPlus program

Inclusion Criteria:

• Male or female >/= 18 years old
• Outpatient with a confirmed diagnosis of Recurrent-Remittent multiple sclerosis or patients at high risk of developing multiple sclerosis after a first demyelinating clinical event
• Patient who initiated Betaferon as described by SmPC less than 2 months ago. The decision of physician is clearly separated from the decision to include the patient in the study
• Treatment naïve patients before the initiation of Betaferon
• OR Patients having interrupted Betaferon for more than 6 months before to start again
• OR Patients receiving a disease modifying drug (DMD) other than Betaferon
• Patient with EDSS score < 4
• Patients approved and signed an inform consent and approved the collect of their data

Exclusion Criteria:

• Contraindications and warning of the respective Summary of Product Characteristics