High Dose Inhaled Mannitol Study

A Pilot Study to Investigate the Feasibility and Tolerability of Inhaling a High Dose of Dry Powder Mannitol (IDPM) Per Breath Administered Via a Dry Powder Inhaler Loaded With a Single Capsule in Subjects With Bronchiectasis

This study is to investigate the safety and tolerability of high doses of inhaled mannitol in subjects with bronchiectasis to further direct development of an improved drug delivery system.

Inclusion Criteria:

• adult subjects with non-CF bronchiectasis
• FEV1 > 50 % predicted and > 1.0L

Exclusion Criteria:

• bronchiectasis due to CF or endobronchial lesion
• respiratory infection requiring IV antibiotics in last 4 weeks
• pregnancy
• significant haemoptysis in last 6 months
• active TB
• end stage ILD
• contraindications as determined by investigator