Effect of a Single Colecalciferol Dose on Insulin Resistance

Effect of a Single Colecalciferol Dose on Insulin Resistance: A Prospective Randomized Trial

A Prospective Double-Blinded, Placebo Controlled, Randomized Trial comparing a single dose of Vitamin D (Colecalciferol) 300.00UI to placebo on patients with insulin resistance. Primary Outcome: Blood glucose and homeostasis model assessment for insulin resistance (HOMA-R) after 90 days. Study hypothesis: Vitamin D treatment may improve insulin resistance and decrease glucose level, since there is an association between hypovitaminosis D and increased insulin resistance.

Inclusion Criteria:

• Fasten Blood Glucose > 100 mg/dL and < 126 mg/dL
• Age > 18 years

Exclusion Criteria:

• Diabetes Mellitus
• Use of metformin
• Vitamin D Use
• Hypercalcemia
• Chronic Hepatitis
• HIV