Role of Interleukin-6 in Exercise

A Lifestyle Intervention Study Investigating the Role of Interleukin-6 in the Beneficial Effect of Exercise on Beta-cell Function in Obese People and Patients With Type 2 Diabetes

The purpose of the study is to understand the role of interleukin-6 during physical activity in patients with type 2 diabetes.

Inclusion criteria:

• Obesity group: BMI 30-40 kg/m2, fasting plasma glucose <6.4 mmol/l.
• Diabetes group: Type 2 diabetes according to American Diabetes Association criteria

Exclusion criteria:

• Anti-diabetic drug other than metformin
• Diabetes duration of more than 5 years
• Inflammatory diseases
• Current infection
• Liver disease (transaminases >2x upper normal range)
• kidney disease (creatinine >1.5 mg/dl for men and 1.4 mg/dl for women)
• pregnancy or breast-feeding, women of child bearing potential not using an acceptable form of contraception
• immunosuppressive disease
• corticosteroid use
• regular non-steroidal antinflammatory drug usage
• history of carcinoma
• history of tuberculosis
• anemia, bleeding disorders
• obstructive pulmonary disease.