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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Valproic acid | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Valproic acid and Ertapenem | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Maximum Plasma Concentration at Steady State (Cmax ss) in Valproic acid single treatment | serial pharmacokinetic plasma concentrations were drawn at 72, 73, 74, 75, 76, 77, 78, 80, and 84 hours according to protocol | |
| Maximum Plasma Concentration at Steady State (Cmax ss) in Valproic acid and Ertapenem combination treatment | serial pharmacokinetic plasma concentrations were drawn at 144, 145, 146, 147, 148, 149, 150, 152, and 156 hours according to protocol | |
| Area Under the Concentration Versus Time Curve in Valproic acid single treatment | serial pharmacokinetic plasma concentrations were drawn at 72, 73, 74, 75, 76, 77, 78, 80, and 84 hours according to protocol | |
| Area Under the Concentration Versus Time Curve in Valproic acid and Ertapenem combination treatment | serial pharmacokinetic plasma concentrations were drawn at 144, 145, 146, 147, 148, 149, 150, 152, and 156 hours according to protocol |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Chang-Seop Lee, MD/Prof. | Chonbuk National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chonbuk National University Hospital | Jeonju | Jeollabuk-do | 561-712 | South Korea |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Dec 27, 2010 | |
| Reset | Jan 11, 2011 | |
| Release | Feb 14, 2011 | |
| Reset | Mar 8, 2011 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Dec 27, 2010 | Jan 11, 2011 | |||
| Feb 14, 2011 |
| ID | Term |
|---|---|
| D014635 | Valproic Acid |
| D000077727 | Ertapenem |
| ID | Term |
|---|---|
| D010421 | Pentanoic Acids |
| D014631 | Valerates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
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| Mar 8, 2011 |
| D009930 |
| Organic Chemicals |
| D005232 | Fatty Acids, Volatile |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D015780 | Carbapenems |
| D047090 | beta-Lactams |
| D007769 | Lactams |
| D000577 | Amides |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |