The Influence of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Renal Function in Patients Undergoing Non-emergent Coronary Angiography

The aim of the current study is to evaluate prospectively whether concomitant administration of RAAS blockers (namely ACE-I and ARBs') influence the change in estimated GFR (eGFR) after administration of contrast media in patients undergoing non-emergent coronary angiography.

Inclusion Criteria:

• 1. Age>18 years
• 2. Subjects on chronic therapy with ACE-I and/or ARBs' (confirmed by electronic records in their medical file)
• 3. Subjects planned to undergo non-emergent coronary angiography.
• 4. Signed informed consent

Exclusion Criteria:

• 1. eGFR<30 ml/min at baseline
• 2. Chronic utilization of NSAIDS and Cox-2 selective inhibitors
• 3. Chronic treatment with mineralocorticosteroid receptor blocker
• 4. Systolic blood pressure<90 mmHg
• 5. Planned staged (repeated) procedure within 48 hours
• 6. Administration of contrast within 14 days prior to the enrollment
• 7. contraindication to stop ACE-I or ARB'S