L-NMMA Dose-response Study in Healthy Subjects

L-NMMA's Effect on Renal and Cardiovascular Variables in Healthy Subjects. A Randomized, Placebo-controlled Crossover Study.

The purpose of this study is to investigate the effect of different levels of nitric oxide inhibition on blood pressure and arterial stiffness in healthy subjects. L-NMMA, an inhibitor of the nitric oxide synthase, is administered as bolus injection followed by continuous infusion, and is expected to raise blood pressure and arterial stiffness according to L-NMMA dose.

Inclusion Criteria:

• Healthy males
• Age 18-35 years
• BMI 18.5-30.0

Exclusion Criteria:

• Tobacco or illicit drug use
• Current use of any prescription or non-prescription drugs
• Alcohol abuse
• History of heart failure, lever failure, chronic kidney disease or cerebral insult
• Diabetes
• Clinical or paraclinical signs of infection
• Pathologic ECG
• Ambulatory blood pressure >140/90 mmHg
• Abnormal blood or urin screening tests