IRB delayed their review for an extensive period of time. Funding for this protocol is no longer available.

The purpose of this study is to collect a blood sample from patients with Chronic Lymphocytic Leukemia (CLL) and from volunteers without CLL.

The blood sample will be used in the laboratory to perform focused studies on Chronic Lymphocytic Leukemia (CLL).

Inclusion Criteria:

• Patients undergoing routine blood draws as part of their ongoing follow-up care for CLL at the Norris Cotton Cancer Center of DHMC.
• Normal donors who have no history of active or prior hematologic malignancy.

Exclusion Criteria:

• Patients who have received cytotoxic drug, oral or intravenous steroid or targeted antibody therapy for their CLL, other hematologic malignancy or other disease process within the past 2 months are excluded. Use of intravenous immunoglobulin (IVIg) is not a reason for exclusion.
• Normal donors who have a history of steroid use, immunosuppression therapy or autoimmune disease are excluded.

Patients at Dartmouth-Hitchcock Medical Center's Norris Cotton Cancer Center