Comparison of Visual Fields: Humphrey Field Analyzer (HFA) SITA Strategy, SCOPE (GATE Strategy) and Humphrey MATRIX Perimeter

Detection of Visual Field Defects and Scotoma Progression in Glaucomatous Optic Neuropathy, Using Short-term Intervals With Automated Scotoma-oriented Perimetry (SCOPE) and the Fast Thresholding Strategy GATE (German Adaptive Threshold Estimation)

The purpose of this study is to compare three perimetric techniques regarding progression of the visual field.

Inclusion Criteria:

• max. ± 8 dpt sph, max. ± 3 dpt cyl
• distant visual acuity > 10/20
• isocoria, pupil diameter > 3 mm
• at least one risk of progression: optic disc (splinter) hemorrhage / cup to disc ratio (CDR) > 0.7 / inter-eye asymmetry of CDR >0.2 / notching of the optic disc /retinal nerve fibre layer (RNFL) defects / intraocular pressure( IOP) >22 mmHg / central corneal thickness < 520 µm / advanced visual field defect stage Aulhorn III / elder than 70 years

Exclusion Criteria:

• pregnancy, nursing
• diabetic retinopathy
• asthma
• HIV+ or AIDS
• history of epilepsy or significant psychiatric disease
• medications known to effect visual field sensitivity
• infections (e.g. keratitis, conjunctivitis, uveitis)
• severe dry eyes
• miotic drug
• amblyopia
• squint
• nystagmus
• albinism
• any ocular pathology, in either eye, that may interfere with the ability to obtain visual fields,disc imaging or accurate IOP readings
• keratoconus
• intraocular surgery (except for uncomplicated cataract surgery) performed < 3 month prior to screening
• history or signs of any visual pathway affection other than glaucoma
• allergies with regard to topic glaucoma medication
• history or presence of macular disease and / or macular edema
• ocular trauma
• medications known to affect visual field sensitivity