Pangenomic Study During Alcoholic Cirrhosis

Genetical Predisposition in Hepatocellular Carcinoma : Pangenomic Link Study During Alcoholic Cirrhosis

Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome.

The determining of a genomic mapping of " single nucleotide polymorphisms " (SNPs) permit to perform some genetic link studies with pathologies without clear hereditary disposition.

In this study, the investigators will identify predictives genetic polymorphism of HCC.

Inclusion Criteria:

• 35 to 70 years old
• Compensated cirrhosis or not
• Caucasian origin of the parents
• Patient with cirrhosis (histological proof or obvious)

Exclusion Criteria:

• HIV, HBV, HCV positive
• Known Homozygotia (C282Y+/+)
• Important hepatocytary iron overload for patient with resection
• HCC non histologically prooved