To evaluate the feasibility, acceptability and safety of using a molecular breast imaging (MBI) Gamma Camera in women at high risk of developing breast cancer

Inclusion Criteria:

• Females ≥18 years of age

• Undergoing annual breast MRI because of a high risk of breast cancer due to any of the following:

  • Known BRCA1 or BRCA2 mutation carriers, or is untested for BRCA but is a first degree relative of a BRCA mutation carrier
  • History of radiation to the chest between 10-30 years of age (e.g. Hodgkin's Disease)
  • History of Cowdens or Li Fraumeni Syndrome
  • A first degree relative with Cowdens or Li Fraumeni Syndrome
  • Prior breast biopsy positive for lobular carcinoma in situ (LCIS) or atypical lobular hyperplasia or atypical ductal hyperplasia (ADH)
  • Family history consistent with a hereditary breast cancer syndrome and estimated personal lifetime cancer risk ≥25% using the IBIS risk evaluator

Exclusion Criteria:

• Pregnant or lactating

• History of invasive breast cancer or ductal carcinoma in situ (DCIS)

• Unable to undergo MRI because of:

  • Renal dysfunction with an estimated creatinine clearance of < 30 ml/min calculated using the Cockcroft-Gault formula
  • Implanted ferrous metal prostheses
  • Claustrophobia
  • Medical or psychological conditions that on assessment, make them unable to complete the procedure
  • Known allergies to Gadolinium-DTPA

• Known allergies to Sestamibi (Miraluma or Cardiolite)

• Prior bilateral mastectomy

• Prior breast biopsy or surgery within 3 months