Early Airway Response to Allergen in Asthmatics (MK-0000-176)

A Two-Part, Randomized, Placebo-Controlled, Crossover Trial to Evaluate the Differential Effects of Inhaled Nedocromil, Oral Montelukast, and Inhaled Mometasone on Markers of the Early Airway Response to Allergen in Asthmatics

This study will assess the Early Airway Response (EAR) associated change in forced expiratory volume in one second (FEV1) and plasma 9α-11ß-PGF2 ('9P') after single dose pretreatment of nedocromil, montelukast, and mometasone.

Inclusion Criteria:

• History of mild to moderate Asthma
• In good general health (except for asthma)
• Stable and free of respiratory infection
• Nonsmoker
• Females highly unlikely to conceive (surgically sterilized, postmenopausal, or agrees to use 2 acceptable methods of birth control)

Exclusion Criteria:

• Nursing mother
• Recent or ongoing upper or lower respiratory tract infection
• Unable to refrain from or anticipates the use of any prescription and non-prescription drugs
• Consumes excessive amounts of alcohol or caffeine
• History of stroke, chronic seizures, or major neurological disorder
• History of cancer
• Received a vaccination within the past 3 weeks