Efficacy of Daily Vitamin D3 Supplementation in Normal Weight Adolescents

A Pilot Study to Evaluate the Efficacy of Daily Vitamin D3 Supplementation in Normal Weight Adolescents

The study is designed to evaluate the increment of serum 25 (OH) vitamin D levels in normal weight adolescents following a 12-week supplementation with Vitamin D3 2000 IU/day.

Twenty normal weight adolescents between ages 12-18 that are age and gender would receive vitamin D3 supplementation at a dose of 2000 IU/day. Levels of 25(OH)vitamin D would be measured at baseline and after 12 weeks.Relationship between 25 OH vitamin D levels and other demographic variables will be assessed.The primary endpoint in this study is the 25 OH Vitamin D level at 12 weeks.

Inclusion criteria:

• Subjects between ages 12 and 18 years with BMI between the 5th and the 85th percentile for age and gender.

Exclusion Criteria:

• Subjects with 25 (OH)- D levels >80 ng/mL
• Serum calcium >10.8 mg/dL
• Serum phosphorus > 5.5 mg/dl
• Pregnancy or nursing
• Current cancer
• Patients on multivitamin supplementation
• Dietary calcium intake exceeding 1500 mg/day
• Hepatic or renal disorders
• Type 1 or Type 2 diabetes mellitus
• Those receiving insulin, metformin, or oral hypoglycemic medications
• Malabsorption disorders (Celiac disease, Cystic fibrosis, Inflammatory bowel disease)