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| ID | Type | Description | Link |
|---|---|---|---|
| Grant number 320030-124886 | Other Grant/Funding Number | Swiss national science fund |
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This study will evaluate the potential effects of a changing metabolic environment on GnRH hypothalamic neurons, by performing studies of LH pulsatility (basal and during clamp studies) in different groups of male subjects fed isocaloric and hypercaloric diets. The participation of other gastro-intestinal tract hormones to these regulations will be systematically evaluated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| isocaloric | Other | impacts of isocaloric nutrition on LH pulsatility in euglycemic and hyperinsulinemic clamps |
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| hypercaloric | Other | impacts of hypercaloric nutrition on LH pulsatility in euglycemic and hyperinsulinemic clamps |
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| per os and IV glucose during the clamp | Other | impacts of per os glucose on LH pulsatility in euglycemic and hyperinsulinemic clamps |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| effect of metabolic variations on LH pulsatility | Dietary Supplement | Isocaloric diet: 1,5 times basal metabolism. Constitution:55% carbohydrates, 15% proteins and 30% fat. Hypercaloric diet: addition of 30% fat and 3 g of fructose/kg of weight to isocaloric diet. PO and IV glucose during clamps: PO administration of 90 mg/kg glucose at 90 minutes intervals during the clamp, and adjustment of the IV perfusion to keep euglycemia. |
| Measure | Description | Time Frame |
|---|---|---|
| Luteinizing hormone (LH) pulsatility | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| François Pralong | CHUV | Principal Investigator |
| Vittorio Giusti | CHUV | Study Director |
| Luc Tappy | CHUV | Study Director |
| Marie-Hélène Pesant | CHUV | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHUVaudois | Lausanne | 1011 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22760567 | Derived | Pesant MH, Dwyer A, Marques Vidal P, Schneiter P, Giusti V, Tappy L, Pralong FP. The lack of effect of insulin on luteinizing hormone pulsatility in healthy male volunteers provides evidence of a sexual dimorphism in the metabolic regulation of reproductive hormones. Am J Clin Nutr. 2012 Aug;96(2):283-8. doi: 10.3945/ajcn.111.030189. Epub 2012 Jul 3. |
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