The purpose of this study is to investigate dose range, safety and efficacy of RVX000222 in subjects with stable coronary artery disease.

One-third of the US population, almost 80 million adults, have cardiovascular disease and mortality associated with heart disease still remains as a leading cause of death around the world. The major risk factors for cardiovascular disease associated with atherosclerosis is dyslipidemia, characterized by high levels of low density lipoprotein (LDL) and/or low levels of high density lipoprotein (HDL). The widespread use of statins in patients at risk for cardiovascular disease has led to lower LDL levels but has had little effect on HDL levels. HDL has a well established role in atherosclerosis and cardiovascular disease protection. HDL mediates the removal of cholesterol from the atherosclerotic plaques for elimination from the body. The cardioprotective component of HDL consists of apolipoprotein A1 (ApoA1). Recent intervention studies with synthetic HDL particles and recombinant ApoA1 have shown that HDL has the capacity to reverse coronary atherosclerosis. Increasing ApoA1 is likely to have a favorable effect on atherosclerotic plaque size and stability, and on cardiovascular diseases. RVX000222 is a member of a novel class of small molecules that are candidates for the treatment of dyslipidemia by increasing plasma levels of HDL through increased ApoA1 transcription.

Inclusion Criteria:

1. Men and women at least 18 years of age.
2. If female, non-pregnant (as determined by a negative serum pregnancy test at Screening), non-lactating, and not of childbearing-potential or willing to practice acceptable form of birth control. If male, be willing to practice an acceptable form of birth control.
3. Documented coronary artery disease such as stable angina, coronary artery bypass graft, myocardial infarction within the past 90 days, or a history of percutaneous coronary intervention greater than 90 days before randomization
4. Taking a stable dose of statin therapy for at least 30 days prior to enrollment into the study with, in the investigators opinion, an unlikely need for statin dose adjustment during the course of the study.
5. Have given signed informed consent to participate in this study

Exclusion Criteria:

1. A female who is pregnant or lactating?

2. Participated in any research study, or been on an investigational drug within the last 30 days?

3. Currently have any of the following Illnesses:

   • Heart disease needing surgical repair
   • Coronary Artery bypass surgery in the last 90 days
   • PCI or Stent placement in the last 90 days
   • Left Ventricular ejection fraction
   • Evidence of cardiac electrophysiologic instability
   • Renal Impairment
   • Uncontrolled Hypertension 160/95 (2 consecutive Measurements)
   • Triglycerides ≥ 400 mg/dl (at Screening)
   • Liver: Total bilirubin > ULN, ALT/AST 1.5 > ULN at Screening
   • History of Drug or Alcohol abuse in last 12 months
   • History of Malignancy ≤ 5 years

4. Currently taking any immunosuppressant's

5. Any changes in stain therapy doses in last 30 days

6. Use of Fibrates at any dose

7. Use of Niacin ≥ 250 mg per day

8. Have any medical or surgical condition which might significantly alter the absorption, distribution, metabolism or excretion of medication including but not limited to any of the following: cholecystitis, Crohn's disease or ulcerative colitis?

9. Have any surgical or medical condition which in the opinion of the Investigator may place the patient at higher risk from his/her participation in the study, or is likely to prevent the patient from complying with the requirements of the study or completing the study?

10. Using other investigational drugs and devices at the time of enrollment, or within 30 days or 5 half-lives of enrollment, whichever is longer?

11. Have a history of noncompliance to medical regimens or unwillingness to comply with the study protocol?

12. Have any condition that in the opinion of the investigator would confound the evaluation and interpretation of efficacy and/or safety data?

13. Directly involved in the execution of this study?