a Comparative Pharmacokinetic Study of Two Oral Formulations of Tacrolimus in Renal Allograft Recipients

a Comparative Pharmacokinetic Study of Two Oral Formulations of Tacrolimus in Renal Allograft Recipients

The aim of this study is to identify the pharmacokinetic differences between two oral forms of Tacrolimus and consequent nephrotoxicity.

Inclusion Criteria:

• ABO-compatible renal transplant recipients

Exclusion Criteria:

• multi-organ transplant
• HIV(+) donor or recipients
• history of malignancy other than skin cancer (except completely cured basal cell ca or squamous cell ca)
• more than three-fold increase in AST or ALT level for 28 days
• pregnancy
• lactation